eCast - Monoclonal Antibodies and Their Interference with Immunohematology Testing (23EL-818)

When:  Mar 29, 2023 from 02:00 PM to 03:00 PM (ET)
Therapeutic monoclonal antibodies are increasingly being used in the treatment of patients with a variety of conditions including malignancy, infection, and inflammatory diseases. The interference caused by monoclonal antibodies in clinical laboratory testing is an emerging concern that requires both recognition and the development of appropriate solutions to mitigate. For example, anti-CD38 and anti-CD47 can cause interference in with routine pre-transfusion testing in the blood bank and thus, might affect the turn-around time in identification of possible alloantibodies and potential delay in compatibility testing for patients requiring blood transfusion. Therefore, it is essential for transfusion services to be aware of such therapy being administered to patients and to develop solutions to overcome this interference to enhance patient safety. This program will provide an introduction to monoclonal antibody therapy, especially ones that may cause interference in serological testing. The interference in blood bank testing caused by these drugs will be described, along with possible solutions to overcome the interference using currently available techniques. Finally, examples of how transfusion services handle such challenges in conjunction with the clinical service will be reviewed.

Learn More
Event Image